Latin name: Hypericum perforatum
Also know as: St. John’s Wort, Saint John’s wort
St. John’s wort refers to a plant by the botanical name of Hypericum perforatum (of the family hypericaceae), with this species in particular being called Common St. John’s wort or Perforate St. John’s wort to distinguish it from other species in the plant genus of hypericum which all share the common name of St. John’s wort.
St. John’s Wort (Hypericum perforatum) is a herb which, through the active component hypericin, works as a dopamine-related anti-depressant and is effective at doing so. This is also the prototypical ‘adverse drug-interaction’ herb; it interacts with several compounds by affecting the several phase I enzymes as well as other drug elimination pathways.
Hypericin, initially thought to be the major psychoactive component of the plant
Hyperforin, a phloroglucinol derivative currently thought to be the major psychoactive component of the plant
St. John’s Wort interferes with the elimination of several drugs and supplements. And should not be used with pharmaceuticals or supplements that are metabolized by this enzyme (like berberine). Consult a medical professional before supplementation of St. John’s Wort if you are taking any drugs or supplements.
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